Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease
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چکیده
منابع مشابه
Porcine Epidemic Diarrhea Virus Replication in Duck Intestinal Cell Line
To the Editor: Porcine epidemic diarrhea virus (PEDV) was first detected in pigs in the United States in May 2013 (1). Since then, according to the American Association of Swine Veterinarians (https://www.aasv.org, see link to number of new cases reported), PEDV has spread to 41 states, and as of October 15, 2014, 8,622 confirmed cases of PEDV infection have been reported in swine. PEDV (family...
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The new porcine epidemic diarrhea (PED) has caused devastating economic losses to the swine industry worldwide. Despite extensive research on the relationship between autophagy and virus infection, the concrete role of autophagy in porcine epidemic diarrhea virus (PEDV) infection has not been reported. In this study, autophagy was demonstrated to be triggered by the effective replication of PED...
متن کاملPorcine epidemic diarrhea virus (PEDV) co-infection induced chlamydial persistence/stress does not require viral replication
Chlamydiae may exist at the site of infection in an alternative replicative form, called the aberrant body (AB). ABs are produced during a viable but non-infectious developmental state termed "persistence" or "chlamydial stress." As persistent/stressed chlamydiae: (i) may contribute to chronic inflammation observed in diseases like trachoma; and (ii) are more resistant to current anti-chlamydia...
متن کاملTMPRSS2 and MSPL Facilitate Trypsin-Independent Porcine Epidemic Diarrhea Virus Replication in Vero Cells
Type II transmembrane serine proteases (TTSPs) facilitate the spread and replication of viruses such as influenza and human coronaviruses, although it remains unclear whether TTSPs play a role in the progression of animal coronavirus infections, such as that by porcine epidemic diarrhea virus (PEDV). In this study, TTSPs including TMPRSS2, HAT, DESC1, and MSPL were tested for their ability to f...
متن کاملCellular hnRNP A1 Interacts with Nucleocapsid Protein of Porcine Epidemic Diarrhea Virus and Impairs Viral Replication
The nucleocapsid (N) protein is a major structural component of porcine epidemic diarrhea virus (PEDV), which is predicted to be a multifunctional protein in viral replication. Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a cellular protein participating in the splicing of pre-mRNA in the nucleus and translation regulation in the cytoplasm. According to our previous proteomic study ...
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ژورنال
عنوان ژورنال: Veterinary Research
سال: 2020
ISSN: 1297-9716
DOI: 10.1186/s13567-020-00865-y